P-glycoprotein functional activity and expression in type 2 alloxan diabetes

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Abstract


On 16 Chinchilla rabbits males of breed with type 2 alloxan diabetes P-glycoprotein functional activity and expression was studied. The diabetes mellitus was modelled by intravenous administration of alloxan monohydrate in the citrate buffer. P-glycoprotein functional activity was assessed by pharmacokinetics of its probe substrate - fexofenadine after its single oral administration. P-glycoprotein expression was investigated by immunohistochemistry method. The inhibition of P-glycoprotein functional activity and expression was followed by decrease of postprandial insulin level and an insulinogenic index and increase of postprandial glucose level in a blood.

About the authors

E N Yakusheva

Ryazan state medical university

Email: e.yakusheva@rzgmu.ru
Ryazan, Russia

D S Titov

Ryazan state medical university

Email: i3762@yandex.ru
Ryazan, Russia

N M Popova

Ryazan state medical university

Email: p34-66@yandex.ru
Ryazan, Russia

A N Ryabkov

Ryazan state medical university

Email: kafedrafarmakologii@mail.ru
Ryazan, Russia

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Copyright (c) 2016 Якушева Е.Н., Титов Д.С., Попова Н.М., Рябков А.Н.

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